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Bioactive Peptides Derived from Milk Proteins

Numerous bioactive peptides are encrypted within the primary structure of milk proteins and released during gastrointestinal digestion and the processing of food (J Dairy Sci, 76: 301-310, 1993, J Dairy Sci, 88: 2348-2360, 2005). Upon release, these peptides have been shown to display antithrombotic, antihypertension, immunomodulation, antimicrobial and mineral absorption activities as well as opioid agonist and antagonist behaviors.

The majority of milk content is comprised of casein and whey proteins. Caseins are phosphoproteins that consist of four major groups: alpha s1, alpha s2, beta and kappa. The main whey proteins are lactalbumin and lactoglobulin.

Bioactive peptides from kappa casein (169 amino acids) are derived from the hydrolyzed C-terminal fragment known as caseinomacropeptide (106-169). The phosphorylated form of caseinomacropeptide, kappacin, has been identified as a potent antimicrobial (Antimicrobial Agents Chemotherapy, 45:2309-2315, 2001, Antimicrobial Agents Chemotherapy, 49: 2322-2328, 2005).

Fragments of kappacin also have shown antimicrobial activity (106-115, 138-158, pS149). Fragment 106-116, named casoplatelin, is antithrombotic with inhibition of platelet aggregation (J Dairy Sci, 76: 301-310, 1993, Biochimie, 80: 155-165, 1998).

Bioactive peptides from alpha s1 casein and beta casein are active opioid agonists, antimicrobial agents as well as ACE (Angiotensin I Converting Enzyme) inhibitors (Eur Food Res Technol, 2007). Beta casein fragments (74-76) and (84-86) are potent ACE inhibitors while fragment (60-64 (casomorphin-5) is an opioid agonist and beta casein 60-66 (casomorphin-7) is an opioid agonist and an ACE inhibitor (J Nutr 134: 980S-988S, 2004, Appl Environ Microbiol, 73:4658-4667, 2007). Alpha s1 casein 90-96 (exorphin) is an opioid agonist while alpha s1 casein fragment 23-34 is an ACE inhibitor.

Bovine lactoferricin is a peptide fragment produced by acid hydrolysis of lactoferrin from cow’s milk. Lactoferricin consist of 25 amino acids (FKCRRWQWRMKKLGAPSITCVRRAF) with the antimicrobial and cytotoxic activity residing in the N-terminus (FKCRRWQWRM, FKCRRWQWRMKK). Lactoferricin has shown to be both antibacterial and antiendotoxin (J Biol Chem, 280: 16955-16961, 2005). Additional studies have shown that lactoferricin has anticancer activity both in vitro and in vivo (J. Pept Sci. 2005; 11: 379-389, Mol. Cancer Ther. 2005; 4: 612-624, Jpn J. Cancer Res. 1997; 88: 184-190, J. Natl Cancer Inst. 2004; 96: 1015-1022).

Catalog #NameSequenceSizePrice
20-9600Kappa casein (106-115) (bovine)MAIPPKKNQD-OH1.0 mg$30
 Antimicrobial   
20-9601Kappa casein (106-116) (bovine) (Casoplatelin) MAIPPKKNQDK-OH1.0 mg$35
 Antithrombotic   
20-9602Kappa casein (138-158 pS149) (bovine)AVESTVATLEA(pS)PEVIESPPE-OH1.0 mg$100
 Antimicrobial   
20-9603Beta casein (60-64) (bovine) (casomorphin-5)YPFPG-OH1.0 mg$15
 Opioid agonist   
20-9604Beta casein (60-66) (bovine) (casomorphin-7)YPFPGPI-OH1.0 mg$20
 Opioid agonist   
20-9607Beta casein (74-76) (bovine)IPP-OH5.0 mg$50
 ACE inhibitor   
20-9608Beta casein (84-86) (bovine)VPP-OH5.0 mg$50
 ACE inhibitor   
20-9609Beta casein (124-133) (bovine)MPFPKYPVEP-OH1.0 mg$25
 ACE inhibitor   
20-9610Beta casein (169-174) (bovine)KVLPVP-OH1.0 mg$15
 ACE inhibitor   
20-9611Beta casein (169-175) (bovine)KVLPVPQ-OH1.0 mg$15
 Antihypertensive   
20-9612Beta casein (210-221) (bovine)EPVLGPVRGPFP-OH1.0 mg$30
 ACE inhibitor   
20-9605Alpha s1 casein (23-34) (bovine)FFVAPFPEVFGK-OH1.0 mg$30
 ACE inhibitor   
20-9606Alpha s1 casein (90-96) (bovine) (Exorphin)RYLGYLE-OH1.0 mg$20
 ACE inhibitor   
20-9613Alpha lactorphin (50-53)YGLF-OH5.0 mg$50
 Opioid agonist   
20-9614Beta lactorphin (102-105)YLLF-OH5.0 mg$50
 Vascular relaxation   
20-9122Lactoferricin (1-10) (bovine)FKCRRWQWRM-NH21.0 mg$25
 Antimicrobial,antiendotoxin,anticancer   
20-9123Lactoferricin (1-12) (bovine)FKCRRWQWRMKK-NH21.0 mg$25
    
20-9124Stearylated-Lactoferricin (1-12) (bovine)Stear-FKCRRWQWRMKK-NH21.0 mg$50
    

Please inquire for technical service and pricing at peptide@qcb.com

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